Differin Gel

£28.00 GBP

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Differin Gel is an acne treatment manufactured by Galderma. The medicine comes as a cream or gel. The active ingredient of Differin is Adapalene, a form of vitamin A. It reduces the growth of keratin skin cells that block pores on the skin, causing acne. It is recommended that you use the gel for three months for better results.

Available Strength 45 g

Available Quantity 1

Differin is a retinoid gel containing adapalene that unblocks pores and calms inflammation to treat mild to moderate acne.

Once-daily gel, applied at night
Treats blackheads, whiteheads and spots
Reviewed by UK-registered clinicians
Discreet, tracked delivery

What is Differin Gel?

Differin Gel contains adapalene, a retinoid that promotes skin cell turnover to prevent the formation of acne. It also has anti-inflammatory properties, reducing redness and swelling associated with acne. Designed for oily skin, Differin Gel is suitable for use on the face and other affected areas, such as the back and shoulders. Consistent use helps to clear existing acne and prevent new breakouts.

How Does Differin Gel Work?

The skin naturally produces sebum to moisturise itself. When generated in excess, it mixes with keratin skin cells and forms a blockage to the sebaceous glands. This causes redness, whiteheads and spots on the face. Differin has an active ingredient Adapalene. It works by reducing keratin surface skin cells and sebum production. It lessens inflammation, helping improve the appearance of the skin. Adapalene also increases the turnover of surface skin cells for natural exfoliation. This results in clearing acne and leaving the skin looking clear and oil-free.

How to use Differin Gel

Follow the instructions and guidance of your healthcare provider while using this products:

Wash your face with a mild cleanser and apply the gel to the affected area.
Use clean fingers to rub in the gel.

When starting treatment with Differin, it produces effects similar to mild sunburn, including mild itching, redness, and warmth. This is normal and should subside.

Possible side effects

Like all other medicine, you may be allergic to Differin. Do a spot check before commencing treatment. Side effects may include:

a burning, stinging, or tingling feeling
dry skin
itching or redness
a rash

Using an oil-free moisturiser can help manage dryness and reduce the risk of scarring.

Warnings and precautions

Avoid using Differin on the skin if you have eczema, cuts, or scrapes.
Avoid contact with the eyes, mouth, or nostrils, and other susceptible body areas. If accidental contact does occur, immediately wash the affected area with warm water.
Limit exposure to strong sunlight and artificial UV light.
If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor.
Do not use Differin when pregnant.

What are the ingredients in Differin Gel?

Adapalene 0.1%, carbomer 934P, macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalene, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide & purified water.

Frequently asked questions

Everything you need to know about Differin Gel before you start.

1. How often should I use Differin Gel?

Apply a thin layer once daily, ideally before bed.

2. How long does it take to see results?

Visible improvements are typically seen between 4 to 8 weeks.

3. Can I use Differin Gel with other acne treatments?

Yes, but consult a healthcare professional before combining treatments.

4. Is Differin suitable for sensitive skin?

It can cause dryness or irritation; use a moisturiser to alleviate these effects.

5. Can I use Differin while pregnant?

No, it is not recommended during pregnancy or when trying to conceive.

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Throughout your treatment, the SwiftDoctor clinical team is available to support you, answer questions, and review your progress.

Step 1

Complete your health questionnaire online in less than five minutes

Takes less than five minutes. Answer a few straightforward questions about your health history, lifestyle, and goals — all from the comfort of your home, with no GP appointment needed. Add your desired medication to your basket and make payment.
Step 2

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Step 3

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Step 4

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Dr S. Bano
Dr Bano is a co-founder of SwiftDoctor. She is an experienced General Practitioner with a special interest in obesity management, medical education, and digital health. She qualified as a doctor from the University of Nottingham in 2011 and has since built a diverse and impactful career in both clinical and educational settings.
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Mr Nasir Ali is a co-founder and the Superintendent Pharmacist at SwiftDoctor. He is a highly experienced Advanced Clinical Practitioner. With extensive experience in primary care, he has worked across GP surgeries and digital health clinics, bringing a deep understanding of both face-to-face and virtual models of care.
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I am a Registered Nurse with 23 years’ experience – I have worked extensively in New Zealand and in the UK and I currently work as an Advanced Clinical Practitioner in the General Practice setting and I have special interests in menopause, diabetes, general practice and the older adult.
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